Intracranial Monitoring to Verify Novel Transcranial Electric Stimulation in an Epileptic Swine Model

Invasive deep brain stimulation has proven to be clinically therapeutic for patients with drug-refractory epilepsy. The aim of this study was develop a novel transcranial electrical device as noninvasive modality seizure treatment. We fabricated and tested it in four swine brains depth electrodes surgically implanted under neuro-navigation. Stimulation two high-frequency alternating currents used cause an interference envelope. Acute focal epilepsy induced by subcortical injection penicillin specific anesthesia protocol. frequency electric field the hippocampus were investigated. frequencies (2 k 2.14 kHz) successfully caused envelope 140 Hz. With 1 mA stimulation, degraded gradually situ 0.68 mV/mm hippocampi. mode attenuated originally epileptic form discharges. No neuronal or axonal injuries noted histopathologically after stimulation. feasibility biosafety our proposed preliminarily verified. Future translational research should focus on electrode deposition parameters quantitative effect.